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Antibacterial activity of Metal Based Nanoparticles–A Comparative view

Author: 
Prema Paulpandian, Selvarani Murugan and Thangapandiyan Santhanam
Subject Area: 
Life Sciences
Abstract: 

The emergence and spread of antibiotic resistance is an alarming concern in clinical practice. This would lead to the development of new antibacterial agents from natural and inorganic substances. In the current scenario, one of the most promising and novel therapeutic agents are the nanoparticles. Hence the present study has been made an attempt to find out the potential metal nanoparticles for the management of human bacterial diseases. Metal nanoparticles (MeNPs) were synthesized by simple, cost effective, chemical reduction method. The synthesized particles were further characterized by X-ray Diffractogram (XRD), Scanning Electron Microscopy (SEM), and Energy Dispersive Spectroscopy (EDS) techniques to analyze size, morphology of the nanoparticles, and quantitative information of elemental metals respectively. Average crystalline size of the particle ranged from 17.85 to 44.87 nm. Bactericidal effect of metal nanoparticles was examined by agar well diffusion technique. Metal nanoparticles showed excellent activity against selected bacterial pathogens. Different classes of bacteria exhibited different susceptibilities to nanoparticles. All the experimental strains depicted highest sensitivity to silver nanoparticles compared to other metal based nanoparticles. Our results suggest that chemically mediated metal nanoparticles could act as an effective alternative for the development of new antibacterial agent to combat resistant problems.

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