Antidotal efficacy of taurine on acetycholinesterase activity and na+/k+-atpase activity in the brain tissue of mercury poisoned rats

The effects of mercury on acetycholinesterase activity, Na+/K+-ATPase activity were studied in different tissues of rats. Experimental groups were control, mercury (5 mg/kg body wt. orally for 30 days). The acetycholinesterase activity, Na+/K+-ATPase activity were significantly decreased in mercury treated brain tissue. Our data indicate that mercury treatment inhibits significantly brain acetycholinesterase activity, Na+/K+-ATPase activity activity, demonstrating the prevalent mercury effect in vivo on central nervous systems. After mercury treatment taurine and glutathione given orally mercury (5.0 mg/kg body wt. orally for 15 days). The present result indicates acetycholinesterase activity, Na+/K+-ATPase activity was decreased in the brain tissue due to antidotal action of taurine and glutathione.