Antihepatotoxic efficacy of nymphaea pubescens (willd.) On acetaminophen induced liver damage in male wistar rats

The antihepatotoxic efficacy of aqueous flower extracts of Nymphaea pubescens (NP) and Silymarin were investigated against acetaminophen induced liver damage in rats. Acetaminophen at the dose of 3gm/kg body weight orally produced liver damage in rats as manifested by the significant rise in serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), bilirubin, cholesterol and decreases the protein level compared with control. Oral administration of flower extracts of Nymphaea pubescens (100, 200, 400mg/kg) and silymarin (25mg/kg) once daily for 28 days to acetaminophen treated rats shows lowered significantly the afore mentioned clinical parameters where as protein level increased. The extract alone treated rats did not adversely affect the serum biochemical estimation. A significant antihepatotoxic efficacy of Nymphaea pubescens extracts was reported.