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Antihyperglycemic effect of tannic acid in streptozotocin induced diabetic rats

Author: 
Babby, A., Elanchezhiyan, C., Suhasini S. and Chandirasegaran, G.
Subject Area: 
Life Sciences
Abstract: 

Tannic acids are a naturally abundant plant phenolic compound in the human diet and are known to have drug property for some diseases. In the present study the antidiabetic efficacy of tannic acid was investigated experimentally. The diabetes was induced by intraperitoneal injection single dose of streptozotocin (50mg/kg b.w). After three days (72hr) of induction of diabetes. The diabetes animals were treated with tannic acid (200mg/kg b.w) and glibenclamide (600µg /kg b.w). Blood glucose estimation was performed every week of the study The tannic acid treated diabetic rats significantly decreased the level of body weight, blood glucose as well as increased level of insulin, glycogen and lowering level of creatine levels. These finding demonstrated that tannic acid possess anti hyperglycemic activity against STZ induced diabetic rats. The antidiabetic effects of tannic acid was compared with standard anti diabetic drug glibenclamide.

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