Today Ayurveda has been gaining popularity throughout the world. The Ayurvedic products are prepared from single herb, combination of herbs, metals, minerals and animal products. The increasing demand for the classical Ayurvedic preparations and the alarming rate of disappearance of the resource of the ingredients, led us to think of the Novel Unifications of Drugs and Formulations. These formulations can give us an effective result provided the Selection of apt drugs is done. Also the consideration of the basic principles of Bhaishajya Kalpana like the role of the Rasa Panchakas, Maatra pramana and understanding the Karma of the drug plays an important role. In the end, formulating in the best suitable form which can give the maximum desired result in a single or compound preparation can be helpful. And, thus development of an effective Novel Unified Drugs and Formulations can be done. This work is an attempt made to throw light on how we can proceed with the novel unification of drugs and formulations (Ayurvedic), its benefits and the challenges faced.
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