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Association of ABO Blood Type with Chemotherapy Sensitivity in Endometrial Cancer

Author: 
Su Xinxin, Wu Suye, Yu Kang and Chen Ledan
Subject Area: 
Health Sciences
Abstract: 

Objective: To explore the relationship of ABO blood group with the clinical efficacy of chemotherapy in endometrial carcinoma. Methods: The clinical data of 320 patients with endometrial carcinoma admitted in our hospital from February 2010 to July 2014 were retrospectively analyzed. Eighty-two cases of type A blood, 86 cases of type B blood, 94 cases of O type blood and 58 cases of AB type blood were included. The blood type of patients and the follow-up results of chemotherapy were analyzed. And the relationship between ABO blood group and the sensitivity of chemotherapy in endometrial carcinoma was analyzed. Results: The chi-square analysis showed that there was no significant difference between the chemotherapy effect and the sensitivity of chemotherapy in group A, B and AB (P >0.05). However, the chemotherapy sensitivity of endometrial cancer patients with O blood was higher than those of the other three groups (P<0.05). Furthermore, Multivariate logistic regression analysis showed that O-type blood was helpful in improving patient chemotherapy sensitivity (OR = 3.057). Conclusions: Type O blood is helpful to improve the sensitivity of chemotherapy in patients with endometrial carcinoma.

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