Association between urticaria activity score (UAS) and dermatology life quality index (DLQI) and change trajectories across all time points

Introduction: Shara Muzmin (Chronic Urticaria (CU) is a common skin disorder characterized by the recurrent appearance of wheals and/or angioedema for more than 6 weeks. The Urticaria Activity Score (UAS) score is commonly used to assess the CU disease activity. CU signs & symptoms affect a wide range of daily activities, from personal care to sleep/rest, work performance, and social relationships. The Dermatology Life Quality Index (DLQI) assesses QOL parameters across several types of dermatologic conditions. Objective: Aims of this study was to determine the association between UAS and DLQI in different follow-ups of patients and improvement UAS and DLQI. Compare change trajectories across all time points (follow-ups) simultaneously between UAS and DLQI using latent class growth models (LCGM). Methods: In this study 29 patients were registered for protocol and used to calculate UAS and DLQI over the time points. Unani pharmacopoeial formulation Qurs Asfar 775mg was given twice daily with water after meals for the period of two weeks. Simple regression model used to determine the association between UAS and DLQI in different follow-ups of patients and improvement, r2 (Pearson) values used to assess the validity of symptom scores and how strong association of them. Latent Class Growth Model (LCGM) used to find individual trajectories of change, allowing correlation of patterns of changes between multiple outcome measures across multiple time points simultaneously. Result: The UAS values were found to positively associated and significantly with DLQI values (r2 = 0.31, P< 0.01) at before stating of this study. UAS values were found to positively associated and significantly with DLQI values (r2 = 0.33, P< 0.01) at 1st follow-up. UAS values were found to highly positively associated and significantly with DLQI values (r2 = 0.72, P< 0.01) at 2nd follow-up. Percentage improvement in UAS values were found to highly positively associated and significantly with DLQI values (r2 = 0.72, P< 0.01). LCGM for A single quadratic trajectory model was found for UAS over the time points using LCGM and two quadratic trajectory model DLQI. Conclusion: The study conclusion that impact of the disease state on a patient’s life: improvements in signs and symptoms, as measured by the UAS, were reflected in improvements in DLQI. The latent class growth models shows that the daily average urticarial activity over seven days and the DLQI over time points are nearly identical.