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Associational study of fto gene polymorphism with obesity in vindhyan region

Author: 
: Neeraj K. Charmkar, Shrikant Kol and Rishabh D. Saket
Subject Area: 
Life Sciences
Abstract: 

Recent studies reported that the occurrence of obesity is determined by both environmental and genetic factor. This study was carried out to investigate whether the FTO gene is associated with obesity and related disorders in the populations of Vindhyan region. In general, the genomic DNA extracted from peripheral blood of healthy individuals and diseased individuals was subjected to PCR for polymorphism screening. The results were in normal subjects as mean of weights were 76.oo Kg, in overweight subject’s weight was calculated 90.4 Kg. In obese subjects mean weight was calculated 105.1 Kg. The mean height was measured 172.2 m, 173.1 m and 172.4 m in Normal weight, overweight and obese subjects respectively. The mean BMI in all three groups were 20.9, 25.3 and 28.4 for Normal weight, overweight and obese subjects respectively. Determination of FTO genotype in all three groups was performed by allele specific PCR reaction. The genotype scored in Normal weight subjects was TT = 40, TA = 46 and AA = 14. In the Overweight subjects it was 37, 45 and 17 for TT, TA and AA respectively. In the obese subjects it is scored 30 for TT, 54 for TA and 17 for AA genotype.

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