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Azoles expressed cyto-protective effects to hepg2 cells

Author: 
Sana Javaid Awan, Faheem Hadi, Madiha Fayyaz, Sabeen Malik, Tahir Maqbool, Somia Shahzadi and Anam Farzand
Subject Area: 
Life Sciences
Abstract: 

Some azoles have proliferative effect on liver cells that showed it can cause angiogenesis as we observed in this study. In this study, HepG2 cells are used as liver cell line. As angiogenesis is the formation of new blood vessels, this drug can initiate the proliferation of more and more cells in liver which can lead to the regeneration of liver cells. This in-vitro study was based on one group of cells treated with our drugs of interest and other was untreated group. The study has shown increased proliferation of treated cells as compared to untreated group in MTT and antioxidant assays in dose dependant manner. As these drugs have proliferative effect, they also showed the increased angiogenesis than the normal cells. On the other hand they can act as antiapoptotic agent to reduce the apoptosis in some diseases like liver fibrosis. Antioxidant assays showed that these drugs played great role in reducing the oxidative stress that a cell can face during injury. SOD and GSH were the antioxidant enzymes which initially play their part in the reduction of superoxide ions. Superoxide ions are free radicals that cause damage to body cells, superoxide dismutase (SOD) and glutathione reductase (GSH) catalyze superoxide ions and convert them into molecular hydrogen and oxygen peroxide and show antioxidant defense response towards damaging free radicals. Thus end results showed that these azoles can have proliferative and regenerative effects on liver cells.

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