Azoospermia in sudanese males with breast cancer: a multiple case report

Background: Male breast cancer (MBC) is an uncommon rare medical condition that is responsible for about 1% of all the malignancies in men as well as for 1% of all of breast carcinoma. Nearly all of the men with breast cancer do not have any distinguishable risk factors. The majority of males with breast cancer presents at older ages as opposed to females with breast cancer. Case presentation: Twenty three cases of MBC, diagnosed between October 2011 and September 2014. Azoospermia was found in eighteen patients, and five patients had oligospermia. For azoospermic MBC patients additional biochemical markers were done (Total testosterone, Follicle-stimulating hormone and total cholesterol) before starting treatment. Results: Follicle-stimulating hormone as well as cholesterol levels were significantly increased in MBC patients when compared to control group, whereas total testosterone level was decreased insignificantly in MBC patients. Conclusion: In this study, the results suggested that the presence of azoospermia increased the chance to develop breast cancer by a mutual mechanism which affects the function of androgen receptors.