Bacteriological Profile of Bile culture and sensitivity pattern of its isolates in adult patient of biliary tract infection in tertiary care hospital of Bihar

Background and objectives: Bacterial infection of biliary tract may cause severe inflammatory response or sepsis. Cholecystitis and cholelithiasis are the most common diseases affecting the gastrointestinal tract. An immediate bile culture and appropriate antibiotic administration are important to control the biliary tract infection. The objective of the study was to study the microbial profile and antibiotic sensitivity pattern in patients with biliary tract infection. This cross sectional descriptive study was conducted at Medicare gastro centre and Sahyog hospital, Patliputra, Patna, India for India for 12 months i.e., from September 2017 to August 2018. Total 100 cases were included in this study. For the prospective group, only patients who had not received antibiotics prior to endoscopic retrograde cholangiopancreatography (ERCP) and had given written informed consent were included. Results: On culture and sensitivity test, 47% have positive growth while 53% have no growth. The most common bacteria was Escherichia coli isolated in 22 (51.16%) patients followed by Klebseilla 9 (20.93%), Pseudomonas 4 (9.30%) Salmonella and Citrobacter each 3(6.98%), and Proteus 2(4.65%). On sensitivity test, all the Gram negative bacilli were sensitive to Tigycycline followed by Colistin, Imipenum and Amikacin. Conclusions: The most common bacteria of symptomatic cholelithiasis are Escherichia coli and Klebseilla followed by Pseudomonas and Salmonella. These bacteria showed maximum sensitive to Tigecycline, Colistin followed by Imipenum and Amikacin. Early detection and determination of antimicrobial susceptibility pattern is important to reduce the mortality and morbidity associated with bile fluid infections.