Sex fixing of mammalian progenies has been a cherished dream of reproductive physiologists since long and it can be a formidable tool in increasing dairy productivity alongside ensuring considerable economic and social benefits. Many attempts to produce sexed off springs have been reported in scientific history and most of them involved techniques producing sexed semen. The present methodology is a novel in vivo technology which uses the administration of a liquid oral formulation which contains active ingredients like monosodiumethanoate and ethanoic acid which when given to females of dairy animals; cows and buffaloes before insemination, yields female off-springs with considerable success rate. The given technology is very simple, effective and has already been patented in USA and many countries of the world including Canada, New Zealand, Australia etc. Major advantages of this may be a rapid increase in the numbers of females of high yielding milch varieties of cows and buffaloes thereby ensuring increased milk production along with benefiting dairy industry too. With so many benefits in its basket of success, this new methodology is even strong enough a candidate to proclaim the arrival of a new class of drugs known as sex fixers in the already diverse and magnificent world of drugs.
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