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Brivaracetam: brief clinical profile of a new antiepileptic drug

Author: 
Parag Bhattacharya, M.D.
Subject Area: 
Health Sciences
Abstract: 

Despite availability of several antiepileptic drugs (AEDs) for the management of epilepsy the problems of inadequate seizure control and disturbing side effects with these drugs persist and hence, quest continues for newer agents with superior clinical efficacy and safety profile. Brivaracetam (BRV) is a new AED that is an analog of levetiracetam (LEV). Its mechanism of antiseizure action seemingly involves selective binding to synaptic vesicle protein 2A, akin to LEV. Its safety and efficacy as an add-on therapy have been studied primarily in adult epilepsy patients with uncontrolled partial-onset seizures. In addition, a few studies have involved patients with generalized seizures, and progressive myoclonic epilepsies. BRV has been found to be efficacious and well tolerated as add-on therapy in partial-onset seizures and generalized seizures. Side effects due to BRV tend to be non-serious, mild-to-moderate in intensity and transient in nature. This article has described the brief pharmacological and clinical profile of BRV.

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