Brucellosis is a zoonotic infection caused by the bacterial genus Brucella. The bacteria are transmitted from animals to humans by ingestion through infected food products, direct contact with an infected animal, or inhalation of aerosols. Whether this entity is highly prevalent among the carcinoma patients, not known and not yet reported. We came across an advanced carcinoma GB with highly reactive Brucellar antibody who optimally responded to antibiotics against Brucella.