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Cardiomyocyte membrane pathogenetic mechanisms and biochemical-Induced endothelial - Coronare in chronic ischemic heart disease

Author: 
Dincă Valeriu-Gabi, Dincă Alexandra-Ligia, Căpitănescu Cristian and Manole Gheorghe
Subject Area: 
Health Sciences
Abstract: 

Regardless of the form which is manifested clinically by degenerative diseases such as cardiovascular diseases, it triggers the pathogenic mechanism as a first modification of the fluidity, that the membrane permeability, in particular of the cellular and mitochondrial. The process begins at membrane level and endothelium coronary to cardiomyocyte sarcolemma through the release of arachidonic acid and catalytic conversion. Secondary functionality disruption occurs receptors and membrane pumps, especially those cationic consequences for the balance transmembrane ion compounds and availability of macro downward energy capital of cardiomyocytes. This work synergistically with ionic concentration camps sarcoplasmatice disorders, particularly Ca2 + will interfere-contract excitation coupling process and that of acto-myosin contractile achieve complex, leading to myocardial contractile deficit installation.

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