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The changes in the serum level of prostatic specific antigen in females with acute urinary tract infection in different age groups

Author: 
Dr. Ahmed Nazar Dhannoon, Dr. Shyamaa Abd Hassan and Dr. Mahmood A. Abdulrahman
Subject Area: 
Health Sciences
Abstract: 

Prostate-specific antigen (PSA) is a valuable tumor marker for prostate cancer. It was believed that PSA was produced exclusively by the epithelial cells of the prostate gland, but a large body of evidence demonstrates that PSA is not a prostate-specific molecule (Giai M 1995). Prostate-specific antigen (PSA) is present at very low concentrations in female serum, but it can now be measured with highly sensitive immunoassays (Yu H, Diamandis EP 1995). PSA has been shown to be expressed in many forms of female tissues. The breast is a major female organ able to produce PSA (Borchert GH 1997). Pregnant women have elevated serum PSA (Yu H, Diamandis EP 1995). PSA levels in serum also vary during menstrual cycles and increase in women with excess androgen . In general a normal serum level of PSA is 0.02ng/dl- 0.06ng/dl (Mardanian F 2011). The objective of the study is to detect the changes of the serum level of PSA in women with acute UTI and show the difference of serum level pre and post- treatment at different age groups. One hundred patients aged from 16 to 77 years presented with features of acute cystitis and diagnosed as a UTI cases definitely by urine culture. Those patients were divided into 2 groups according to menopausal state. Group A pre-menopausal females 56 patients . Group B post-menopausal females 44 patients. The pretreatment mean level of PSA for group A 0.09nag/dl. while the mean level PSA for group B was 0.3nag/dl. The result shows that the post-treatment mean level for group A was 0.02nag/dl . while for group B was 0.09nag/dl. We concluded that the serum PSA level is elevated in females with acute UTI and decline post-treatment with highly detectable level in both pre and post-treatment with post-menopausal females.

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