
Oral malignancy is the major health problem worldwide. Sixteen million new cases of cancers are estimated by 2020. Inspite of various advancement in treatment modalities including chemotherapy and radiotherapy, the survival rate has not been increased. Chemopreventive agents are essential micronutrients whose role is extensively known in physiological and also in pathological state associated with malignancy. This paper highlights the mechanism of action how chemopreventive agents suppress the carcinogenesis and also related to the clinical trials.