CALL FOR PAPERS

CERTIFICATE

IMPACT FACTOR 2018

Subject Area

  • Life Sciences / Biology
  • Architecture / Building Management
  • Asian Studies
  • Business & Management
  • Chemistry
  • Computer Science
  • Economics & Finance
  • Engineering / Acoustics
  • Environmental Science
  • Agricultural Sciences
  • Pharmaceutical Sciences
  • General Sciences
  • Materials Science
  • Mathematics
  • Medicine
  • Nanotechnology & Nanoscience
  • Nonlinear Science
  • Chaos & Dynamical Systems
  • Physics
  • Social Sciences & Humanities

Why Us? >>

  • Open Access
  • Peer Reviewed
  • Rapid Publication
  • Life time hosting
  • Free promotion service
  • Free indexing service
  • More citations
  • Search engine friendly

Plagiarism Detection

IJCR is following an instant policy on rejection those received papers with plagiarism rate of more than 20%. So, All of authors and contributors must check their papers before submission to making assurance of following our anti-plagiarism policies.

Chronic toxic-metal poisoning and neurodegenerative diseases

Author: 
Alessandro Fulgenzi, Daniele Vietti and Maria Elena Ferrero
Subject Area: 
Life Sciences
Abstract: 

Background: Many epidemiological studies describe the role of toxic metals in the complex etiology of neurodegenerative diseases (ND): multiple sclerosis (MS), Parkinson’s disease (PD), Alzheimer’s disese (AD), amyotrophic lateral sclerosis (ALS) Urine-sample analysis after provocation testing with chelating agents allows quantification of the toxic-metal burden in human subjects, including those affected by ND. Our objective was to compare the toxic-metal levels in the urine of patients with ND and those of healthy controls from the same geographical area (Italy), and to evaluate the effect of chelation therapy using calcium disodium ethylenediaminetetra acetic acid (CaNa2EDTA, or EDTA) to eliminate the chronic poisoning caused by toxic metals. Methods and Findings: Inductively coupled plasma mass spectrometry (ICP-MS) was used to evaluate the levels of 21 toxic metals (Al, Sb, As, Ba, Be, Bi, Cd, Ce, Gd, Pb, Hg, Ni, Pd, Pt, Te, Tl, Th, Sn, Ti, W, U) in the urine samples of 1147 patients who underwent the EDTA chelation test: 671 were affected by ND (MS, PD, AD, and ALS), 138 by non-ND (e.g. fibromyalgia, rheumatoid arthritis, peripheral neuropathies), and 338 were healthy controls (HC). Study design: before the start of chelation therapy, the patients underwent a “chelation test” to verify the possible toxic-metal burden. Thereafter, their toxic-metal burden was periodically monitored for more than one year. Our patients did not display the presence of Bi and Ti, while Be, Pt, Te, and Sn were present in only a small number of patients; Ab, Ba, and Th were more present, but to a lesser extent compared with Al, As, Cd, Cs, Gd, Pb, Tl, W, U, Hg, Ni, Pd. Interestingly, Be, Pd, Pt, Te, Tl, Th, Sn, W, and U were never present in MS patients, but were present in other ND patients. Poisoned patients affected by diseases were more numerous than HC. Except for As, toxic-metal presence was significantly more elevated in the ND patients. Repeated EDTA chelation therapy was able to remove all toxic metals with no adverse effects. One important limitation was that the source of intoxication was not always evident. Conclusions: Our results underline the important relationship between the chronic body burden of some toxic metals and the presence of ND. Chelation therapy using EDTA can remove the toxic-metal burden.

PDF file: 

IJMCE RECOMMENDATION

ONLINE PAYPAL PAYMENT

CURRENT ISSUE

NEWS

CHIEF EDITOR

Rosane Cavalcante Fragoso, Brasil

ASSOCIATE CHIEF EDITOR

   

Jean-Marc SABATIER
Chief Scientific Officer and Head of a Research Group
France

Advantages of IJCR

  • Rapid Publishing
  • Professional publishing practices
  • Indexing in leading database
  • High level of citation
  • High Qualitiy reader base
  • High level author suport

EDITORIAL BOARD

Luai Farhan Zghair
Iraq
Hasan Ali Abed Al-Zu’bi
Jordanian
Fredrick OJIJA
Tanzanian
Firuza M. Tursunkhodjaeva
Uzbekistan
Faraz Ahmed Farooqi
Saudi Arabia
Eric Randy Reyes Politud
Philippines
Elsadig Gasoom FadelAlla Elbashir
Sudan
Eapen, Asha Sarah
United State
Dr.Arun Kumar A
India
Dr. Zafar Iqbal
Pakistan
Dr. SHAHERA S.PATEL
India
Dr. Ruchika Khanna
India
Dr. Recep TAS
Turkey
Dr. Rasha Ali Eldeeb
Egypt
Dr. Pralhad Kanhaiyalal Rahangdale
India
DR. PATRICK D. CERNA
Philippines
Dr. Nicolas Padilla- Raygoza
Mexico
Dr. Mustafa Y. G. Younis
Libiya
Dr. Muhammad shoaib Ahmedani
Saudi Arabia
DR. MUHAMMAD ISMAIL MOHMAND
United State
DR. MAHESH SHIVAJI CHAVAN
India
DR. M. ARUNA
India
Dr. Lim Gee Nee
Malaysia
Dr. Jatinder Pal Singh Chawla
India
DR. IRAM BOKHARI
Pakistan
Dr. FARHAT NAZ RAHMAN
Pakistan
Dr. Devendra kumar Gupta
India
Dr. ASHWANI KUMAR DUBEY
India
Dr. Ali Seidi
Iran
Dr. Achmad Choerudin
Indonesia
Dr Ashok Kumar Verma
India
Thi Mong Diep NGUYEN
France
Dr. Muhammad Akram
Pakistan
Dr. Imran Azad
Oman
Dr. Meenakshi Malik
India
Aseel Hadi Hamzah
Iraq
Anam Bhatti
Malaysia
Md. Amir Hossain
Bangladesh
Ahmet İPEKÇİ
Turkey
Mirzadi Gohari
Iran