Fistula in ano resemblance to Bhagandar described in Ayurvedic classics. This is one of the common disorders in anorectal surgery. Fistula in ano usually develops from the abscess in anorectal area, which burst in anus or rectum inside and outside over skin near anus in perianal region. In spite of development of medical science in to the sky Fistual in ano is still a difficult disease to treat without recurrence. In Ayurveda ksharasutra therapy is a gold standard technique to treat this condition with minimal recurrence rate. In ksharasutra therapy a medicated thread is inserted into the fistulous track which act upon and dissolve the infection and heal the track. The most common kshara used for this therapy is Apamarga Kshara. Apamarga kshara is an excellent drug in this disease but in the due course of treatment some patient felt some kind of discomfort as excessive pain, discomfort, itching and some patients even withdraw the therapy. These discomforts may be due to involvement of different doshas in disease, so they get aggravated. So keeping in mind the Dosh predominant theory Kadali, Aragvadha and Palash are taken to use in Ksharasutra therapy of the Vataj, Pittaj and Kaphaj Bhagandar. This study was conducted in two group and every group divided in three subgroups. Trail group patients are treated with Kadali, Aragvadha and Palash ksharasutra and control group patients were treated with Apamarga ksharasutra. Data were analysed statically and encouraging results have been found.
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