Combination of dexmedetomidine and propofol toprovide effective sedation for dise (drug induced sleep apnea) procedure in patients with obstructive sleep apnea (a case series)

Introduction: Drug-induced sleep endoscopy (DISE) is a diagnostic tool for evaluating obstruction of upper airway during sedation and predicting surgical outcomes. Case Series: We conducted this case series in total 10male patients with Obstructive Sleep Apnea (OSA). The patientswere sedated with 1mcg/kg of Dexmedetomidine administered over 10 minutes, followed by 0.3-0.7 mcg/kg/hr infusion and Co-administration of inj. Propofol 0.5mg/kg according to lean body weight to achieve a target level of BIS of 60-70 for optimal sedation. Once the desired sedation level was reached, a flexible fiberopticvideolaryngoscope was inserted to observe upper airway obstruction. Discussion: Combination of Dexmedetomidine and Propofol provided safe and effective sedation during DISE procedure in patients with OSA. Synergistic effect of both the drugs provided sedation with better hemodynamic stability and desirable BIS. Conclusion: Dexmedetomidine and propofol combination resulted in effective sedation, inducing a state closely resembling natural sleep without notable cardiac or respiratory depression.