
Background: Furcation area offer unique and challenging problems, creates situations in which routine periodontal procedures are somewhat limited and special procedures are generally required. Materials and Methods: This study is comparative evaluation of DFDBA+ CGF +PRF versus open flap debridement with PRF in grade II/III furcation with follow up of 12 months. The study population included 30 subjects, who visited the out-patient department of periodontics, Govt Dental College and Hospital Srinagar with complaint of bleeding and sensitivity, diagnosed as chronic periodontitis. After conducting routine examinations, Relative attachment and probing depth were measured. The measurement of Relative attachment was made with ocllusal stent as guiding value. Probing depth was made with UNC-15 periodontal probe. Furcation depth was measured with Probe (UNC-15). Furcation defect was filled with CGF+PRF+DFDBA in test group and open flap debridement with PRF in control group, flap was coronally advanced in both test and in control group. Results: Concentrated growth factor and PRF with DFDBA have been shown to be a promising and successful approach for the treatment of furcation defect. Its gaining clinical attachment significantly manages both the gingival recession and furcation involvement simultaneously. Conclusion: Within the limitation of this study, significant improvement with autologous CGF+PRF+DFDBA implies its role as a regenerative material in the treatment of furcation defects.