Giant duodenal ulcer perforations are common in surgical practice and very less series are reported in literature. The actual size of perforation is known definitely only intraoperatively. Giant duodenal ulcer is defined as perforation of size equal to or greater than 2 cm in diameter. Various techniques such as omentopexy, omental plugging, control tube duodenostomy, partial gastrectomy, jejunal-serosal patch, jejunal-pedical graft, proximal gastrojejunostomy, or even gastric disconnection have been described in literature. Here we are presenting comparative study of 36 cases of giant duodenal ulcer perforation collected prospectively from 2000 to 2014.Al-Ameen Medical college, Bijapur.