A comparison of etomidate and thiopentone as induction agents in laparoscopic surgeries

This study was designed to compare the hemodynamic effects of etomidate and thiopentone during induction in laparoscopic surgeries. Stimulation of laryngeal and tracheal tissues during intubation causes catecholamine discharge with an increase in sympathetico-adrenergic activity and also an increase in systemic blood pressure and heart rate. These increases begin with laryngoscopy. Various induction agents are used for laparoscopy. Etomidate is characterized by hemodynamic stability , minimum respiratory depression and cerebral protective effects. Its lack of effect on sympathetic nervous system and its effect on increased coronary perfusion makes it an induction agent of choice. Thiopentone is a barbiturate derivative having rapid onset of action and rapid awakening with single induction dose due to rapid uptake.