In this study, the aim was to compare the prevalence of ABO and Rhesus blood groups in mothers and their neonates born in a tertiary care hospital in North India. In this cross-sectional study, the results showed that the B gene was most common, followed by O gene and further followed by A gene in both mothers and their neonates. The blood group A was 3rd most common blood group and the blood group AB and Rh negatives were infrequent in both mothers and their neonates. In this cross-sectional study, the results also showed that most often about 42.63% mothers had same blood group as that of neonates, about 27.13% mothers and neonates had ABO incompatibility, about 23.26% mothers and neonates had other compatible blood groups, about 6.01% mothers and neonates had Rh incompatibility and least often, about 0.97% mothers and neonates had both ABO and Rh incompatibility.
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