A comprehensive review on oral submucous fibrosis

Oral submucous fibrosis is an irreversible mucosal change due to hypersensitivity; the attributing factors are mainly divided into local and systemic. Local factors are dietary substances such as Chilies, betel quid (Gutkha) and Areca nut which imparts main contribution for the condition. Systemic factors, nutritional deficiency, autoimmunity, and genetic susceptibility. It is associated with other conditions such as trismus and fibrosis, burning sensation with initiation from an early mucosal inflammation. It is an irreversible condition with high probability of malignant transformation. So, it is imperative to have an insight related to this debilitating disease and its etiology, pathology, and treatment modes and prevention and insight about mechanisms of malignant transformation and to provide and apply possible management and decisively work towards treatment modalities. Hence the present article OSMF reviewed the etiology, pathophysiology, clinical features & management.