CERTIFICATE

IMPACT FACTOR 2021

Subject Area

  • Life Sciences / Biology
  • Architecture / Building Management
  • Asian Studies
  • Business & Management
  • Chemistry
  • Computer Science
  • Economics & Finance
  • Engineering / Acoustics
  • Environmental Science
  • Agricultural Sciences
  • Pharmaceutical Sciences
  • General Sciences
  • Materials Science
  • Mathematics
  • Medicine
  • Nanotechnology & Nanoscience
  • Nonlinear Science
  • Chaos & Dynamical Systems
  • Physics
  • Social Sciences & Humanities

Why Us? >>

  • Open Access
  • Peer Reviewed
  • Rapid Publication
  • Life time hosting
  • Free promotion service
  • Free indexing service
  • More citations
  • Search engine friendly

Conjugated linoleic acid (cis-9, trans-11 isomer) modulated tnf-α induced cell adhesion molecules expression in human umbilical vein endothelial cells (HUVEC)

Author: 
Nima Sanadgol, Leyla Vafadar Ghasemi, Gholamreza Motalleb, Ehsan Sanadgol, Ali AfsharimoghadamNima Sanadgol, Leyla Vafadar Ghasemi, Gholamreza Motalleb, Ehsan Sanadgol, Ali Afsharimoghadam
Subject Area: 
Life Sciences
Abstract: 

Conjugated linoleic acid (CLA) is a polyunsaturated fatty acid (PUFA) that has been shown in recent years to have numerous potential benefits for human health. The vascular cell adhesion molecules play principal role in inflammatory diseases. Blocking the expression of these molecules or preventing their interaction with the receptors has been shown to be important in controlling various inflammatory diseases. However, the effect of CLA on endothelial cell adhesion molecules is unknown. We investigated the effects of cis-9, trans-11 Isomer of CLA on expression of intracellular cell adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and endothelial selectin (E-selectin) in HUVECs and comparison with, linoleic acid (LA). Endothelial cells co-incubated with or without TNF-α (0.001µg/ml) in the presence of LA or CLA (100µM/L) for 16-h before assessing the expression of adhesion molecules. The expression of adhesion molecules in HUVEC was assayed by ELISA and RT-PCR technique. CLA but not LA, decreased VCAM-1 and ICAM-1 expression in both mRNA and soluble levels in TNF-α activated cells (P<0.001). Furthermore, CLA modulated mRNA concentration of E-selectin, without any effect in soluble level of this molecule (P> 0.05). While LA didn’t show significant effect on TNF-α induced expression of adhesion molecules, a progressively increasing inhibitory activity was observed, for CLA. Therefore, CLA could be used as a novel agent for controlling various pathological conditions associated with up-regulation of inflammatory adhesion molecules at least in HUVECs. The role of CLA in the modulation of inflammation in vivo requires further study.

PDF file: 

CALL FOR PAPERS

 

ONLINE PAYPAL PAYMENT

IJMCE RECOMMENDATION

Advantages of IJCR

  • Rapid Publishing
  • Professional publishing practices
  • Indexing in leading database
  • High level of citation
  • High Qualitiy reader base
  • High level author suport

Plagiarism Detection

IJCR is following an instant policy on rejection those received papers with plagiarism rate of more than 20%. So, All of authors and contributors must check their papers before submission to making assurance of following our anti-plagiarism policies.

 

EDITORIAL BOARD

CHUDE NKIRU PATRICIA
Nigeria
Dr. Swamy KRM
India
Dr. Abdul Hannan A.M.S
Saudi Arabia.
Luai Farhan Zghair
Iraq
Hasan Ali Abed Al-Zu’bi
Jordanian
Fredrick OJIJA
Tanzanian
Firuza M. Tursunkhodjaeva
Uzbekistan
Faraz Ahmed Farooqi
Saudi Arabia
Eric Randy Reyes Politud
Philippines
Elsadig Gasoom FadelAlla Elbashir
Sudan
Eapen, Asha Sarah
United State
Dr.Arun Kumar A
India
Dr. Zafar Iqbal
Pakistan
Dr. SHAHERA S.PATEL
India
Dr. Ruchika Khanna
India
Dr. Recep TAS
Turkey
Dr. Rasha Ali Eldeeb
Egypt
Dr. Pralhad Kanhaiyalal Rahangdale
India
DR. PATRICK D. CERNA
Philippines
Dr. Nicolas Padilla- Raygoza
Mexico
Dr. Mustafa Y. G. Younis
Libiya
Dr. Muhammad shoaib Ahmedani
Saudi Arabia
DR. MUHAMMAD ISMAIL MOHMAND
United State
DR. MAHESH SHIVAJI CHAVAN
India
DR. M. ARUNA
India
Dr. Lim Gee Nee
Malaysia
Dr. Jatinder Pal Singh Chawla
India
DR. IRAM BOKHARI
Pakistan
Dr. FARHAT NAZ RAHMAN
Pakistan
Dr. Devendra kumar Gupta
India
Dr. ASHWANI KUMAR DUBEY
India
Dr. Ali Seidi
Iran
Dr. Achmad Choerudin
Indonesia
Dr Ashok Kumar Verma
India
Thi Mong Diep NGUYEN
France
Dr. Muhammad Akram
Pakistan
Dr. Imran Azad
Oman
Dr. Meenakshi Malik
India
Aseel Hadi Hamzah
Iraq
Anam Bhatti
Malaysia
Md. Amir Hossain
Bangladesh
Ahmet İPEKÇİ
Turkey
Mirzadi Gohari
Iran