Background: A limited number of researchers have paid attention to the psychosocial well‐being of patients affected with vitiligo. We review the psychosocial effects of vitiligo, individuals deal with them, and the psychiatric morbidity in vitiligo patients. The effects of the psychological state on the disease itself together with the potential therapeutic implications are reviewed. Based on these data, we suggest how to further improve patient management. Psychological interventions such as cognitive behavioral therapy are helpful in improving body image, self-esteem, and QOL of patients with vitiligo and also appear to have a positive effect on the course of the disease. Coping responses are related to the level of self-esteem. Those patients with a positive self-image can cope better with physical disabilities. Aim of the study To determine depression and anxiety in vitiligo patients visiting the dermatology clinic at King Abdul-Aziz hospital in Makkah AlMokarramah in comparison to the normal population. Method: A cross-sectional study has been conducted in the dermatology clinic at King Abdul-Aziz hospital in Makkah AlMokarramah during the data collection period using the depression scale and the anxiety scale. Results: The majority of the subjects had extremely severe depression by the depression scale and extremely severe anxiety by the anxiety scale. There is a significant negative correlation between socio-demographic data (age, duration) and depression respectively were (r= -0.836, -0.917)and p-value =0.001, Also a significant negative correlation between socio-demographic data(age, duration)and anxiety respectively were(r= -0.816, -0.897)and p-value =0.001. Conclusion: Addressing psychosocial factors is an important aspect of the management of vitiligo, particularly in patients from communities where the disease is greatly stigmatizing. In evaluating the psychological impact of vitiligo it is important to consider the patient's life situation including the social support network and the attitude of colleagues and family members as even "mild" disease may greatly distress the patient.
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