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Design and evaluation of ph triggered in situ ophthalmic gel of moxifloxacin hydrochloride and ketorolac tromethamine combination

Author: 
Shashank Nayak N. and Srinivasa U.
Subject Area: 
Health Sciences
Abstract: 

Eye drops are the most conventional ophthalmic drug delivery system available in the market with various patient compliance problems. In this current work pH triggered in situ ophthalmic gel of Moxifloxacin hydrochloride and Ketorolac tromethamine combination are prepared by using carbopol 934 as gelling agent and carboxy methyl tamarind kernel powder and Hydroxy propyl methyl cellulose K15M as viscosity enhancing agent and rate controlling polymer, Benzalkonium chloride was used as preservative in the above formulation. The formulations were sterilized by autoclaving at 1210 C at 15 PSI at 20 min. The formulations were evaluated for various parameters like visual appearance, clarity, pH, gelling capacity, drug content and in vitro diffusion studies, antimicrobial study, stability study. The drug release pattern was analysed by derivative spectroscopy using derivative spectroscopy. The release pattern of the best formulation indicated that both the drug showed zero order release pattern for a period of 12 hours thus increasing the contact time of drug with ocular tissues and reducing the nasolacrimal drainage. The drug-drug and drug excipient compatibility study was done by FTIR. From this current work it can be concluded that In situ ophthalmic gel is an alternative to convention drug delivery system.

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