Introduction: Preeclampsia is the main cause of maternal and fetal morbidity and mortality in the world. Its etiopathogenesis is multifactorial and is still a challenge and subject of research. Purpose: To predict the occurrence of preeclampsia in patients in the second trimester of pregnancy who are asymptomatic with the help of immunological biomarkers. Materials and Methods: Total of 100 patients is being examined and is divided in two groups. An examined group of 50 patients was with notch of the uterine artery and the interaction of the more pro-inflammatory with anti-inflammatory cytokines (TNF-α, IL-1α, IL-2, IL- 6 versus IL-4, IL-10). The ELISA (Enzyme-linked immunosorbent assay) methodology is used. Also a control group of 50 patients without uterine artery notch is examined for comparison and drawing appropriate conclusions. Results and Discussion: The obtained results of increased proinflammatory and reduced regulatory anti-inflammatory immune cells and cytokines, creates an uncontrolled state of inflammation. The rise in IL6 together with TNF-α with a significance of p <0.01 and the decrease in mean in anti-inflammatory cytokines (IL4 and IL10) compared to the control group with the investigated group are important and credible parameters for the expected further development of the preeclampsia state. This disorder is thought to contribute to the overall preeclampsia pathophysiology. Conclusion: Uterine Doppler together with immunological biomarkers increases the sensitivity and specificity of diagnostics of the clinical preeclampsia syndrome.
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