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Development and validation of rp-hplc method for simultaneous estimation of zaltoprofen and paracetamol in bulk and tablet formulation

Author:

Annasaheb S Gaikwad, Yogesh R Thombare, Nisha S Mhaske and Mahendra B Datir

Subject Area:

Life Sciences

Abstract:

A simple, sensitive, linear, precise and accurate RP-HPLC method for simultaneous estimation of Zaltoprofen and Paracetamol in bulk and tablet formulation as developed and validated. Chromatographic conditions used are stationary phase Grace C18 column (250mm × 4.6mm, 5µ particle size. The mobile phase Methanol: Phosphate buffer (PH 3.0) in the ratio 75:25 v/v and flow rate was maintained 0.8ml/min, detection wavelength was 241nm. The retention times were 3.101min and 5.838min for Zaltoprofen and Paracetamol respectively. Calibration plot were linear R2 =0.9994 over the concentration range 10-18µg/ml for Zaltoprofen, R2 = 0.9994 for the Paracetamol 40-72µg/ml. No interference from any component of pharmaceutical dosage form was observed. The proposed method has been validated as per ICH guidelines, validation studies revealed that method id specific, rapid, reliable and reproducible. The developed method successfully employed for routine quality control analysis in the combined pharmaceutical dosage form.

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