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Development of spinocellular carcinoma with the presence of hpv pairs 16 and 18, identified by pcr, after previous diagnosis of vulgar wart

Author: 
Rodolfo Georgevich Neto, Camila Correia dos Santos, Halbert Villalba, Mônica Grazieli Corrêa and Elcio Magdalena Giovani
Subject Area: 
Health Sciences
Abstract: 

The human papilloma virus (HPV) has a high potential for transmission and contamination among the population. HPV infection is closely related to host cell differentiation and remodeling. The virus changes the proliferative capacity of the epithelium, the more superficial stratified layers remain proliferative, including the most differentiated strata, generating exophytic epithelial growth. The oncogenic potential is related to the insertion of viral DNA into the host genome. HPV integrates into the genomic DNA of the host epithelial cell and mediated by two viral proteins from the E6 and E7 viral region, prevents cell cycle arrest. HPV 16 and 18 subtypes have a high incidence in detections of malignant neoplastic lesions. This work assisted a case of HPV detection in a preventive process of malignant neoplasias, being part of the research supported by the Brazilian PROSUP / CAPES program. Clinical dentistry and laboratory procedures are described in detail in order to understand the possible relation between HPV and carcinogenesis in the oral region. The key role of patient follow-up after the appearance of an HPV lesion is highlighted.

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