Diagnostic methods with high sensitivity and specificity are highly essential for effective tuberculosis management. Endemic nature of the pathogen, cross-reaction in vaccinated individuals and poor growth rate makes it’s diagnosis more complicated and urges the need for improved diagnostic methods to limit progression and the spread. Advancements in technology in combination with conventional knowledge on TB and molecular genetics approaches have helped to achieve considerable progress in TB diagnostics. This review highlights different methods of TB diagnosis ranging from phenotypic methods to genetic approaches, which are approved by WHO and are in the pipeline for commercialization.
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