CERTIFICATE

IMPACT FACTOR 2021

Subject Area

  • Life Sciences / Biology
  • Architecture / Building Management
  • Asian Studies
  • Business & Management
  • Chemistry
  • Computer Science
  • Economics & Finance
  • Engineering / Acoustics
  • Environmental Science
  • Agricultural Sciences
  • Pharmaceutical Sciences
  • General Sciences
  • Materials Science
  • Mathematics
  • Medicine
  • Nanotechnology & Nanoscience
  • Nonlinear Science
  • Chaos & Dynamical Systems
  • Physics
  • Social Sciences & Humanities

Why Us? >>

  • Open Access
  • Peer Reviewed
  • Rapid Publication
  • Life time hosting
  • Free promotion service
  • Free indexing service
  • More citations
  • Search engine friendly

Does chemoradiotherapy induce thrombotic risk in advanced nasopharyngeal carcinoma

Author: 
Endang Listianingsih Tarigan, Abdul Rachman Saragih, Herman Hariman and Stephen CL Koh
Subject Area: 
Life Sciences
Abstract: 

Background: Nasopharyngeal cancer (NPC), a highly prevalent malignant disease is a leading cause of death in several regions in Southern China including countries in Southeast Asia. In Indonesia, NPC is a major multi-ethnic problem and it remains one of the most confusing and commonly misdiagnosed disease until advanced stages. Chemotherapy improves treatment but also contribute towards increased risk of thrombosis in cancer. Methods: A total of 12 subjects (males n=8; Stage II n=2; Stage III n=2, Stage IV n=8) were recruited into the study. Blood sampling was performed at pre- and post-chemotherapy cycles 1 to 3 followed by radiotherapy. PT (INR), aPTT, TT ratios were determined together with D-dimer, platelets and platelet aggregation. Results: The mean age of NPC patients was 43.3 ±9.0 years. Pre-chemotherapy ratios of PT, aPTT and TT were <1.0 which indicated a hypercoagulable state. No significant variation in these parameters were seen post-chemoradiotherapy except that D-dimer were elevated postradiotherapy and platelet numbers significantly reduced from cycle 2. However, 4 patients (33.3%) with Stage IV disease had D-dimer levels above the normal level (<500 ng/mL) at post-radiotherapy were further analysed. This suggest a further enhanced hypercoagulable and hyperfibrinolysis state and thromboembolic risk following radiotherapy in this small cohort study. Conclusion: Chemoradiotherapy enhance the risk of thromboembolism in 33.3% of advanced NPC patients in this small study group. These findings indicate that not all NPC patients show enhanced risk of thromboembolism following chemoradiotherapy.

PDF file: 

CALL FOR PAPERS

 

ONLINE PAYPAL PAYMENT

IJMCE RECOMMENDATION

Advantages of IJCR

  • Rapid Publishing
  • Professional publishing practices
  • Indexing in leading database
  • High level of citation
  • High Qualitiy reader base
  • High level author suport

Plagiarism Detection

IJCR is following an instant policy on rejection those received papers with plagiarism rate of more than 20%. So, All of authors and contributors must check their papers before submission to making assurance of following our anti-plagiarism policies.

 

EDITORIAL BOARD

CHUDE NKIRU PATRICIA
Nigeria
Dr. Swamy KRM
India
Dr. Abdul Hannan A.M.S
Saudi Arabia.
Luai Farhan Zghair
Iraq
Hasan Ali Abed Al-Zu’bi
Jordanian
Fredrick OJIJA
Tanzanian
Firuza M. Tursunkhodjaeva
Uzbekistan
Faraz Ahmed Farooqi
Saudi Arabia
Eric Randy Reyes Politud
Philippines
Elsadig Gasoom FadelAlla Elbashir
Sudan
Eapen, Asha Sarah
United State
Dr.Arun Kumar A
India
Dr. Zafar Iqbal
Pakistan
Dr. SHAHERA S.PATEL
India
Dr. Ruchika Khanna
India
Dr. Recep TAS
Turkey
Dr. Rasha Ali Eldeeb
Egypt
Dr. Pralhad Kanhaiyalal Rahangdale
India
DR. PATRICK D. CERNA
Philippines
Dr. Nicolas Padilla- Raygoza
Mexico
Dr. Mustafa Y. G. Younis
Libiya
Dr. Muhammad shoaib Ahmedani
Saudi Arabia
DR. MUHAMMAD ISMAIL MOHMAND
United State
DR. MAHESH SHIVAJI CHAVAN
India
DR. M. ARUNA
India
Dr. Lim Gee Nee
Malaysia
Dr. Jatinder Pal Singh Chawla
India
DR. IRAM BOKHARI
Pakistan
Dr. FARHAT NAZ RAHMAN
Pakistan
Dr. Devendra kumar Gupta
India
Dr. ASHWANI KUMAR DUBEY
India
Dr. Ali Seidi
Iran
Dr. Achmad Choerudin
Indonesia
Dr Ashok Kumar Verma
India
Thi Mong Diep NGUYEN
France
Dr. Muhammad Akram
Pakistan
Dr. Imran Azad
Oman
Dr. Meenakshi Malik
India
Aseel Hadi Hamzah
Iraq
Anam Bhatti
Malaysia
Md. Amir Hossain
Bangladesh
Ahmet İPEKÇİ
Turkey
Mirzadi Gohari
Iran