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An echocardiographic study of left ventricular function disturbances in chronic severe anemia

Author: 
Dr. Farquana Qushnood and Dr. Zaheera Sultana, S.
Subject Area: 
Health Sciences
Abstract: 

Background and Objectives: Anemia is a serious health problem in India. Anemia which is often untreated or inadequately treated is emerging as a potential contributor to the development and progression of cardiovascular disease. Hence the present study was undertaken to find out LV function changes in severely anemic patients by Echocardiography. Methodology: Present study was conducted in Al-Ameen Medical College and Government district Hospital, Bijapur. 31 anemic patients (aged 18-40 yrs) and equal number of age and gender matched non anemic healthy individuals were volunteers. All anemic patients and controls were subjected for hemoglobin estimation and M mode 2D Echocardiography. Echocardiographic parameters- IVSTd, LVIDd, LVPWd, IVSTs, LVIDs, LVPWS, EDV, ESV, SV, CO, EF, FS were studied. Statistical analysis was done by Student’s unpaired‘t’ test. Results: Statistically significant variations were found in parameters- Wt, BSA, BMI, PR, DBP, LVIDd, LVIDs, EDV, ESV, SV, CO, EF, FS in anemic patients compared to controls. Ht, SBP, IVSTd, LVPWd, IVSTs, LVPWs showed no variation. Interpretation and Conclusion: The findings of increased LVIDd, LVIDs, EDV, ESV, SV, CO and decreased EF, FS, in anemic patients compared to controls may be as a consequence of hyperdynamic circulatory state leading to vascular and cardiac changes. These changes are mainly due to increased preload, decreased afterload, changes in cardiac geometry. These factors increases systolic wall stress resulting in eccentric LV hypertrophy and over time leads to LV systolic dysfunction.

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