The present study has been taken up to observe the toxic effect on a fresh water snail, Pila globosa induced by Dithane M-45. The present study shows alteration in lipase activity level in hepatopancrease and renal organ of Pila globosa at acute and chronic exposure of Dithane M-45. Significant depletion in (P<0.05) in lipase activity level was observed in hepatopancreas and renal organ at chronic exposure while slight depletion was observed in both experimental tissues at acute exposure of Dithane M -45.