A trial was conducted to study the effect of integrated use of nutrients on growth, yield and qulity of sweet orange cv. Mosambi at regional research station, Jhargram of Bidhan Chandra Krishi Viswavidyalaya. Growth in terms of canopy height, basal girth and canopy volume were significantly improved with application of nutrients and maximum growth was observed in plants received with (N200P75K150g + neem cake 2.0kg)/ plant / year followed by (N200P75K150g + neem cake 2.0kg + VAM)/plant/year. Highest average fruit yield (9.0kg/plant) was obtained with application of 200g nitrogen, 75g phosphorus and 150g potassium in combination with 2.0kg of neem cak as compared with control (3.0kg/plant). The fruit quality in terms of total soluble solids, total sugar, TSS: acid ratio and vitamin C content of fruits were obtained from plants received with (N200P75K150g + neem cake 2.0kg). The highest fruit yield was associated with the foliar N.P.K concentration of 2.30, 0.12 and 1.30 percent respectively.