Effects of systemic lupus erythematosus in pregnancy women: A review of clinical features and outcomes of 122 pregnancies

Background: The pregnancy outcome in Chinese women with systemic lupus erythematosus (SLE) has been controversial. Research looking at predictive factors in this population is sparse in China. Objective: The aim of this study was to determine the frequencies of abnormal pregnancy outcomes in a Chinese cohort and to identify clinical factors predicting adverse fetal and maternal outcomes in Chinese women with SLE. Patients and Methods: We retrospectively reviewed the medical records of 122 pregnant women with SLE diagnosed patients from 2011 to 2017, regarding the association of the clinical features including lupus nephritis, pre-eclampsia and the adverse outcomes in Qilu Hospital of Shandong University. Univariate and multivariate analyses were used to evaluate the predictors of maternal and fetal outcomes. Results: The Mean age of pregnant women with SLE was29.15±3.99years and mean average SLE duration was 5.03±4.64 years. Of 122 pregnant women, 83.6% women had live births and the preterm live birth was 32.0%. Average mean of baby weight was 2254.79±1114.51 grams. The most common maternal complication was premature rupture of membranes 18.0%, followed by pre-eclampsia or eclampsia 17.2%. Conclusion: Age group, SLE duration, hemoglobin, erythrocyte sedimentation rate (ESR), anticardiolipin antibodies (aCL) were independent predictor of fetal loss for pregnant women with SLE. Further studies were needed to investigate the predictor factors of Chinese pregnant women with SLE.