Disorders of lipid metabolism results in Hyperlipoproteinemia which is one of the modifiable factor and leading cause of Coronary Artery Diseases.Clinical trials of relatively short term duration indicate that 2% reduction in CAD rates from each 1% reduction in serum cholesterol. Though Homoepathic treatment is found to be effective in various clinical conditions reelated to CAD, no biochemical correlation were attempted. This prospective study included primary hyperlipoproteinemia, diabetes mellitus, Hypertension and coronary artery disease groups. A total number of 86 patients were followed for about 2 years. Analysis of this study indicated a highly significant reduction in total cholesterol ( < 0.001 ), LDL cholesterol ( < 0.001), and non –HDL cholesterol ( 0.001). C:HDL and LDL: HDL were also reduced after treatment. There was reduction from high risk group to low risk group and optimal levels. This study had also demonstrated the efficacy in reduction of risk for develoment of CAD in 10 years, reduction of fasting and post prandial blood sugar in diabetes mellitus, as well as systolic and diastolic pressure in Hypertension. This study indicates efficacy of Homoeopathic method of treament in Life style disorders - Hyperlipidemia, Hypertension, Diabetes Mellitus, Coronary Artery diseases as well as the prevention of development of CAD.