Sickle Cell Anaemia is a genetic blood disorder caused by abnormal hemoglobin that damages and deforms red blood cells. The abnormal red cells break down, causing anemia, and obstruct blood vessels, leading to recurrent episodes of sever pain and multiorgan ischemic damage. The Indian System of Medicine Ayurveda has valuable information about herbs and mineral for human uses. T-AYU-HM™ is an extract of eight Indian origin herbal plants and three purified minerals. In laboratory studies it strongly inhibits sickling of red cells in patients with sickle cell diseases and it has been shown in initial clinical evaluation in state of Gujarat, India. Preparations and standardizations are as FDA standard. The Antisickling activity of T-AYU-HM™ was evaluated in vitro using Emmel test. The poly Herbo-Mineral formulations exhibited attractive antisickling activity, thus, supporting the claims of the traditional healers and suggesting a possible correlation between the chemical composition of Herbo-Mineral and its uses in traditional medicine.