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An Efficient Reduction Process At Key Intermediate Stages In Dabigatran, Domperidone And Olanzapine Api’s

Author:

Shiva Rama Krishna Samala, Srishylam, V., Kranthi Kumar, T., Sreenivasulu, R. and Devanna

Subject Area:

Life Sciences

Abstract:

Objective: The present paper describes the simple and efficient protocol for the reduction of key intermediates in three API’s like Dabigatran, Domperidone and Olanzapine using Iron metal with Ammonium formate as main reagents with suitable solvent system. In Dabigatran and Domperidone the conversions are nitro to amine and in Olanzapine nitrile reduction followed by cyclization.

PDF file:

32510.pdf

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