Background: Monitoring of Plasmodium falciparum resistance to antimalarial drugs in Côte d'Ivoire takes place on the classic sentinel sites determined by the National Program Control for Fight against Malaria (PNLP) according to the therapeutic efficacy testing approach and/ or coupled with molecular studies. However, areas outside these sentinel sites are not regularly monitored; hence the non-updating of data on the epidemiological profile of malaria in these areas. Methods: A cross-sectional and descriptive study was conducted over a period of 3 months at the Regional Hospital of Séguéla (from September to November 2019) to describe the epidemiological profile of malaria in this region of North-West Côte d'Ivoire (Séguéla). Results: A total of 3057 patients were included in the study, involving 1621 female (53%) and 1436 male (47%). The average age was 15 years with extremes ranging from 4 months to 65 years. The realization of the thick drops made it possible to count 1614 (53%) positive cases of which the majority were children of less than 5 years. The parasite density varied from 112 to 300000 parasites/µl of blood with an average of 9724 parasites/µl of blood. Plasmodium falciparum was the only species found. The parasite index reported during this study was 52.8%. Conclusion: Malaria is endemic in the health district of Séguéla with a prevalence higher than that observed nationally.
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