Central venous cannulation (CVC) is an invasive procedure that is considered as a minor surgery requiring local anaesthesia. It can be also used where placement of peripheral IV cannula is difficult. Even though such catheters supply essential vascular access. Employment of these catheter takes patient into the risk of local and systemic infection complications including local site infection, catheter related bloodstream infections (CRBSIs), septic thrombophlebitis, endocarditis, and other metastatic infections.The infection caused by CVC is colligated with increased morbidity, mortality, duration of hospitalization and medical costs. To prevent catheter related bloodstream infectionsuse of antiseptic solutions for catheter insertion is used to dis-infect the skin. Povidone-iodine solution is the most frequently used agent for CVC. In some countries chlorhexidine is more used than povidone-iodine and is available in different formulations (0.5 - 4%) and can be taken single or in combined with other products like alcohol & cetrimide.
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