To evaluate serum lipid levels in oral cancer: a pilot study

Introduction: Lipids are the major cell membrane components essential for cell growth and division and the maintenance of cell integrity of normal and malignant tissues. Alterations in serum lipid profile have long been associated with malignancies. Aim: The aim of this study was to estimate the serum lipid profile in oral cancer patients and to study the relationship and clinical significance of serum lipid level and risk of oral cancer. Material and Methods: In this study total of 30 cases were taken, out of which 20 were of oral cancer and 10 were controls. Fasting lipid profile including cholesterol(C), triglycerides (TGL), high density lipoprotein (HDL), low density lipoprotein (LDL) and very low density lipoprotein (VLDL) were analysed. Results: Decrease levels of C, TGL, HDL, and LDL were observed in patients with oral cancer as compare to controls. VLDL values as such were not significant. Conclusion: An inverse relationship was found between serum lipid profile and oral cancer which may have an early diagnostic or prognostic role in oral cancer.