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Evaluation of antimicrobial activity, Minimum Inhibitory Concentration (MIC) & Anti-tumor activity of Elettariacardamomum and Ferula assa-foetida leaves

Author: 
Samer Shamshad and Savita Chaurasia
Subject Area: 
Life Sciences
Abstract: 

Aim: In the present study we compared the antimicrobial and Anti Tumoractivity of two varieties of Indian medicinal plants. Tetracycline was used as the positive control in anti-microbial assay. Methods: Agar well diffusion assay, Carrot disc assay. Results: Methanoic extracts of Elettariacardamomum and Ferula assa-foetida leaves were tested against Escherichia coli (gram negative bacteria), Staphylococcus aureus, Bacillus subtilis, Streptococcus mutans (gram positive bacteria) and Candida vulgaris (fungi) using agar well diffusion assay. The Anti-tumor activity was evaluated by Carrot disc assay. The range varied from 4 mm to 7 mm against E.coli, 7 to 11 mm against Staphylococcus aureus, 12 to 15 mm against B. subtilis, 4 to 10 mm Streptococcus mutans and lastly mild antifungal activity of 2 mm was observed for Candida vulgaris. All the extracts presented comparatively higher MIC values than that of tetracycline (a standard antibiotic used as positive control). Both plants exhibit significant anti-tumor activity. Significance and impact of study: Based on these findings presents a good scope for developing a potential antimicrobial and Anti-tumor agent in suitable compounds formulation with least amount of side effects.

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