CALL FOR PAPERS

CERTIFICATE

IMPACT FACTOR 2018

Subject Area

  • Life Sciences / Biology
  • Architecture / Building Management
  • Asian Studies
  • Business & Management
  • Chemistry
  • Computer Science
  • Economics & Finance
  • Engineering / Acoustics
  • Environmental Science
  • Agricultural Sciences
  • Pharmaceutical Sciences
  • General Sciences
  • Materials Science
  • Mathematics
  • Medicine
  • Nanotechnology & Nanoscience
  • Nonlinear Science
  • Chaos & Dynamical Systems
  • Physics
  • Social Sciences & Humanities

Why Us? >>

  • Open Access
  • Peer Reviewed
  • Rapid Publication
  • Life time hosting
  • Free promotion service
  • Free indexing service
  • More citations
  • Search engine friendly

Plagiarism Detection

IJCR is following an instant policy on rejection those received papers with plagiarism rate of more than 20%. So, All of authors and contributors must check their papers before submission to making assurance of following our anti-plagiarism policies.

Evaluation of convolvulus pluricaliswhole plants extract for its acute oral toxicity in albino rats

Author: 
Dr. Gangadhara Swamy, Dr. Suresh R Rao and Dr. Rajendra Holla
Subject Area: 
Health Sciences
Abstract: 

Background: Convolvulus pluricalis an herbal drug is known medicinal plant used extensively in the Indian system of medicine. In this regard to this several experiments has been conducted to know the LD50 and the actual effective (therapeutic) dose, but the results are inconsistent. Thus the acute oral toxicity study was carried out to find out the median lethal dose of the Hydro-Alcoholic extract whole plant extract of Convolvulus pluricalis, which will be used for further experiment to know its effective dose and the clinical trials. Objectives: The present study is carried out to evaluate the Hydro-alcoholic whole plant extract of Convolvulus pluricalis (HACP) for its acute oral toxicity in Albino rats. Methods: Acute oral toxicity of Hydro-Alcoholic whole plant extract of Convolvulus pluricalis was assessed in Albino rats with three doses of the extract at 175, 550 and 2000mg/kg bwt. The mortality, clinical signs & the body weight of the rats were recorded in 0 (prior to administration), 7th& 14th days. At the end of the observation period rats were sacrificed and studied for any histological changes in brain, heart, liver and kidney tissues. The results: Administration of HACP to the rats for 175, 550 &2000mg/kg bwt, were normal up to 1 hour and later on showed a sedative effect for the following 4 hours. Decreased motor activity was observed only in 550 &2000mg/kg bwt of HACP administered rats. All the animals appeared normal from day one to throughout the experimental procedure. No significant changes were seen in the histological structure of the brain, liver, kidney & heart. Conclusion: HACP signified as Nero- suppressant, the drug can be used in the treatment of neurological disorders characterized by hyperactivity of the neurons. The present data could provide adequate confirmation of the safety of CP for further experimental studies on a standardized formulation of the whole plant extract.

PDF file: 

IJMCE RECOMMENDATION

ONLINE PAYPAL PAYMENT

CURRENT ISSUE

NEWS

CHIEF EDITOR

Rosane Cavalcante Fragoso, Brasil

ASSOCIATE CHIEF EDITOR

   

Jean-Marc SABATIER
Chief Scientific Officer and Head of a Research Group
France

Advantages of IJCR

  • Rapid Publishing
  • Professional publishing practices
  • Indexing in leading database
  • High level of citation
  • High Qualitiy reader base
  • High level author suport

EDITORIAL BOARD

Luai Farhan Zghair
Iraq
Hasan Ali Abed Al-Zu’bi
Jordanian
Fredrick OJIJA
Tanzanian
Firuza M. Tursunkhodjaeva
Uzbekistan
Faraz Ahmed Farooqi
Saudi Arabia
Eric Randy Reyes Politud
Philippines
Elsadig Gasoom FadelAlla Elbashir
Sudan
Eapen, Asha Sarah
United State
Dr.Arun Kumar A
India
Dr. Zafar Iqbal
Pakistan
Dr. SHAHERA S.PATEL
India
Dr. Ruchika Khanna
India
Dr. Recep TAS
Turkey
Dr. Rasha Ali Eldeeb
Egypt
Dr. Pralhad Kanhaiyalal Rahangdale
India
DR. PATRICK D. CERNA
Philippines
Dr. Nicolas Padilla- Raygoza
Mexico
Dr. Mustafa Y. G. Younis
Libiya
Dr. Muhammad shoaib Ahmedani
Saudi Arabia
DR. MUHAMMAD ISMAIL MOHMAND
United State
DR. MAHESH SHIVAJI CHAVAN
India
DR. M. ARUNA
India
Dr. Lim Gee Nee
Malaysia
Dr. Jatinder Pal Singh Chawla
India
DR. IRAM BOKHARI
Pakistan
Dr. FARHAT NAZ RAHMAN
Pakistan
Dr. Devendra kumar Gupta
India
Dr. ASHWANI KUMAR DUBEY
India
Dr. Ali Seidi
Iran
Dr. Achmad Choerudin
Indonesia
Dr Ashok Kumar Verma
India
Thi Mong Diep NGUYEN
France
Dr. Muhammad Akram
Pakistan
Dr. Imran Azad
Oman
Dr. Meenakshi Malik
India
Aseel Hadi Hamzah
Iraq
Anam Bhatti
Malaysia
Md. Amir Hossain
Bangladesh
Ahmet İPEKÇİ
Turkey
Mirzadi Gohari
Iran