Evaluation of dacryodes edulis (g. don) hj lampulp oil effects on biochemicals parameters in mice

Background: The oil of D. edulis pulp fruits is known for its medicinal and nutritional potentialities. Evaluation of hepatic and renal function is a major step in the study of the pharmacological activities of plant extracts. Objective: To evaluate the effects of D. edulis (DEO) oil on biochemical parameters in mice. Methods: Lipid (TG, CT, HDL-C), transaminases (ALT and AST) and creatinin levels were determined in the serum after oral administration of DEO (5 and 10 ml/kg), for 6 weeks. The LDL-C level was calculated according to the Friedwald formula. The biochemical parameters levels of DEO treated animals were compared to those of the control animals. Results: The results obtened in dicate that DEO administration did not cause any significant modification of the animals weight and the concentrations of TG, CT and HDL-C.A dose-dependent decrease in LDL-C, ALT, AST and CR was observed in animals treated with DEO, compared to control animals. Conclusion: The results of this study show that DEO does not significantly alter the lipid profile but provides protection for hepatocellular and renal function.