Evaluation of hepatic biomarkers among sudanese pregnant women with preeclampsia in khartoum state

Back ground: Liver damage associated with preeclampsia may array from mild hepatocellular necrosis with serum enzyme aminotransferase and lactate dehydrogenase abnormalities to the ominous hemolysis and elevated liver enzyme. Aim: the aim of this study was to assess the serum liver function test (LFT) in preeclampsia women in Khartoum State Materials and Methods: This cross-sectional case control study conducted in Jabel Awalia Hospital Khartoum state, in the period from March to June 2020. Hundred subjects were involved, fifty were preeclamptic women as cases and fifty normal pregnant women as control group. A venous blood was collected from each participant, obtaining the serum; Serum level of liver biomarkers (ALT, AST, and ALP), total bilirubin and direct bilirubin were measured by calorimeter method in fully Automated Biochemistry Analyzer (Mindary Bs380). Data were analyzed using the SPSS version 20 t-test was used for comparison of means between two groups and Pearson’s correlation test was used to test the association between study parameters and variables, P-value < 0.05 is considered significant. Results: pregnant women with preeclampsia had significantly increase in means of serum AST, ALT, total bilirubin and direct bilirubin . (P value= 0.033, 0.019 0.002, 0.000) respectively .There was a significant decrease in the serum albumin level in case compared to control group (P. value =0.039), while there were insignificant different of serum ALP, total protein between two groups (P value= 0.811, 0.44). There were significant positive correlation .between AST and (ALT, ALP and total and direct bilirubin) (p vaule <0.05) while there were significant negative correlation between albumin, total protein and AST. Also found significant positive correlation between ALT and other hepatic markers (ALP, albumin , total and direct bilirubin) (p vaule <0.05). Conclusion: The outcomes of this study show that hepatic biomarkers in pregnant women with preeclampsia was higher than normal pregnant women, therefore, we can predict more likely to develop HELLP syndrome in pregnant women with preeclampsia.