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Evaluation of the hepatoprotective activity of gomphrena celosioides (amaranthaceae) on wistar rats intoxicated with tetrachloride Carbon

Author: 
Maxime Machioud SANGARE; Jean Robert KLOTOE; Victorien DOUGNON; Jean-Marc ATEGBO; Anatole LALEYE; Patrick EDORH; Lauris FAH; Maximin SENOU; Frédéric LOKO; Karim Laye DRAMANE
Subject Area: 
Life Sciences
Abstract: 

Gomphrena celosioides is a plant used in traditional medicine for treating liver diseases. Tetrachloride Carbon (CCl4) was used to induce liver toxicity on rats. This hepatotoxicity caused a significant rise in liver enzymes, bilirubin and liver cell damage. The different treatments with aqueous extract of Gomphrena celosioides (EAG) at a dose of 500 mg / kg of body weight (BW) and silymarin (SIL) recognized for its hepatotoxic properties at a dose of 300 mg / kg BW decreased levels of these parameters and repaired liver damage. Preventive treatment of animals with EAG and SIL have decreased the rate of serum transaminases, alkaline phosphatase and bilirubin with a yield of 65.06% for EAG and 78.34% for SIL about alanine amino transferase (ALT). Curative treatment of animals with EAG and SIL have a yield of 56.35% to 70.45% against the EAG to SIL about the ALT. Hepatoprotective activity of EAG is more protective than curative and is comparable to SIL’s activity. Possible mechanisms for this activity may be due to the action of antioxidants in flavonoids, present in the EAG.

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