Introduction: Occupational accidents are common in any area of work, including hospitals. Every year, hundreds and thousands of health care workers are exposed to deadly diseases like HIV and Hepatitis C through needle stick injuries. Objectives: To assess the knowledge on prevention of needle stick injury before and after the skill training program, to determine the effectiveness of skill training program by comparing pre test and post test level of knowledge and to associate the knowledge on prevention of needle stick injury with skill training programme on needle stick injury. Materials and methods: Quasi experimental one group pre and post-test research design was used for the study. 143 B.Sc. nursing students of 1stand 2ndyears were selected as participants by simple random lottery sampling technique. A structured questionnaire was used to assess the knowledge and skill on prevention of needle stick injury. Results: In pre-test 43.4% of the students had inadequate knowledge, 49% showed moderate knowledge and 7.7% had adequate knowledge. After the administration of skill training programme 47.6% had moderate, 52.4% had adequate knowledge, 40.6% had moderate skill and 59.4% had high skill in practicing safe recapping techniques and disposal methods after the skill training program in post test. Conclusion: The skill training programme was an effective mode to create awareness and helps to improve the knowledge and practice of safety measures to prevent needle stick injury among nursing students.
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