Expression of Ki67 and CerbB-2 in gall bladder, oesophageal, small intestinal and colorectal adenocarcinomas: A study from a tertiary care hospital in western U.P

Our study revealed a significantly high expression of Ki67 in neoplastic epithelial glands of gall bladder, oesophageal, small intestinal and colorectal adenocarcinomas as compared to the non neoplastic areas. The Ki67 labelling index was higher in moderately and poorly differentiated areas as well as mucopapillary and signet ring type adenocarcinomas. There was no particular relation with stage of tumor spread/depth of tumor invasion. CerbB-2 was significantly overexpressed in gall bladder and colorectal adenocarcinomas. Expression was higher in tumors of advanced stage and greater depth of invasion. There was no significant association with tumor grade or type. In esophageal and small intestine adenocarcinomas, expression was not related to either tumor stage or grade.